Dengue fever is a tropical disease endemic to more than 100 countries. Therefore, dengue virus type 2 can be transmitted transovarially in aedes. Dengue is the most prevalent arthropodborne viral infection of humans in tropical and subtropical countries. The origin of the name dengue is unknown, but is thought to derive from the swahili kadinga pepo or disease of the devil corrupted to the spanish word dengue which described the fastidious gait exhibited by sufferers as they walk. Dengue is among the most important mosquitoborne viral disease in the world. If you are bitten by an infected mosquito, symptoms can take up to 2 weeks to develop but usually last less than a week. Pdf in order to understand more about the epidemiology of dhf, a study of the type of dengue viruses and vectors under natural conditions was carried. Nevertheless, scientists understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appears.
Molecular cloning methods have led to a greater understanding of the structure of the rna genome and definition of virus specific structural and nonstructural proteins. When their distribution is combined with rapid population growth, unplanned urbanization, and increased international travel, extensive transmission of denv is likely in africa figure 2,4. People get dengue from the bite of an infected mosquito. All four denv serotypes are prevalent in the sub tropical regions of the world and infect 50100 million individuals. Pdf double infection of heteroserotypes of dengue viruses in field.
Generally, dengue is classified as a blood infection and the main reaction of the human body to dengue virus. It is caused by the 4 serotype of dengue virus and is transmitted with in human through female aedes mosquito. Mosquitoes in the uk do not spread the dengue virus. Also known as dengue fever, an acute mosquitoborne viral illness of sudden onset that usually follows a benign course with headache, fever, prostration, severe joint and muscle pain, swollen glands lymphadenopathy and rash. In the last 50 years, dengue incidence has increased 30fold, worldwide. It is caught by people visiting or living in asia, the americas or the caribbean. Denv is a singlestranded, positivesense rna virus of the genus flavivirus transmitted by aedes mosquitoes. The presence the dengue triad of fever, rash, and headache and other pains is particularly characteristic of dengue. Dengue virus denv 14 represents a major emerging arthropodborne pathogen. Slaves in the west indies who contracted dengue were said to have dandy fever because of their postures and gait. Demam berdarah dengue dbd atau dengue haemorhage fever dhf adalah. Dengue fever can be caused by any one of four types of dengue virus. Dengue virus is an epidemic facing many asian countries.
Symptoms include fever, headache, nausea, vomiting, rash, pain in the eyes, joints, and muscles, and minor bleeding. Complication of dengue fever can give rise to a more severe. Besides fever, the disease is characterized by an extreme pain in and stiffness of the joints. Each year, an estimated 390 million people are infected. Four distinct serotypes of the dengue virus dengue1, dengue2, dengue3, and dengue4 exist, with numerous virus strains found worldwide. A new dengue virus has been confirmed for the first time in the country. This enveloped virus contains a positive singlestranded rna genome. The fda announced approval of dengvaxia vaccine for prevention of dengue disease caused by all dengue serotypes in people ages 916 who have laboratoryconfirmed prior infection and live in endemic areas. It goes by other names including breakbone or dandy fever. In this table, provisional cases of selected notifiable diseases. Dengue fever is common in tropical areas, so take extra precautions if you travel somewhere with this type of climate. Over the past 5 decades, cases of epidemic or sporadic dengue have been reported in many countries.
Dengue virus denv belongs to the flavivirus genus of the flaviviridae family. Wednesday, march 16, 2016 healthday news an experimental vaccine against dengue the mosquitoborne virus behind a very painful illness. Current and historical conditions indexed list of current and historical nationally notifiable conditions. There are four different strains of the dengue virus.
Dengue is a global issue some diseases in the united states, as in other countries, must be reported by physicians and hospitals to public health authorities as a means of establishing the baseline occurrence of the disease or condition. Every year, dengue virus denv infections cause more than 50 million cases, 500 000 hospitalizations and 12 500 deaths in the world1, 2. Focusing on the pathogenesis of dengue, a pattern of acute viral infection can be seen. Dengue has been around for hundreds of years and has spread throughout the. The world health organizations have estimated that between 50 and 100 million people suffer from dengue fever each year. Morfologi yang khas adalah gambaran lira lyreform yang putih pada. Dec 06, 2009 dengue virus is an epidemic facing many asian countries. Dengue fever is the second most widespread in the world. A retrospective study found no evidence that yellow fever vaccination in dengueendemic areas increases risk for severe dengue fever.
Victims of dengue often have contortions due to the intense joint and muscle pain. Africa and can serve as vectors of dengue virus denv. The disease is caused by four serologically and genetically distinct viruses termed dengue virus denv 1, 2, 3 and 4. Analysis of genotype diversity and evolution of dengue. Dengue virus disease dengue fever, or dengue is a viral disease spread by mosquitoes in many tropical and subtropical parts of the world including africa, asia, south america and occasionally, some parts of northern queensland. Dengue is the most rapidly spreading mosquitoborne viral disease in. The table includes total number of cases reported in the united states, by region and by states, in accordance with the current method of displaying mmwr data. High fever severe nausea mild nosebleeds joint pain new appearance of skin rashes 3. Global incidence of dengue has grown dramatically in recent decades. Denv is a member of flaviviridae family and is transmitted to humans by infected female aedes genus, especially aedes aegypti or aedes albopictus. Dengue virus is a member of the flaviviridae family, along with yellow fever, west nile, japanese encephalitis and tickborne encephalitis tbe viruses. Since then, multiple dengue virus serotypes have become endemic in most countries of tropical. Transmission dengue virus can be transmitted from the bite of an infected aedes mosquito.
Dengue fever df is common mosquito born disease caused by dengue virus 1. Dengue virus is one of the most widespread mosquitoborne viruses worldwide, with an estimated annual infection rate around 390 million. Casestudy 17 yearold female admitted into princeton plainsborough hospital. Dengue fever is a virus transmitted to humans through bites from the aedes mosquito, a daybiting mosquito. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease. Scientists at punebased national institute of virology, who spotted it and had been tracking it, said the new. An international consortium of scientists worked to map out the antigenic differences in various strains of dengue virus.
Complication of dengue fever can give rise to a more severe form, called dengue hemorrhagic fever. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. Aedes aegypti sebagai vektor demam berdarah dengue. Each denv has four or more genetic groups or genotypes. Dengue fever is a dangerous and depilating disease, and its a growing threat to global health. The dataset consisting of 990 complete genome sequences of strains of dengue virus serotype 2 denv2 was compiled from the dengue virus variation resource at national center for biotechnology information resch et al. There are four characterised serotypes of dengue virus, designated denv1 to 4. Molecular cloning methods have led to a greater understanding of the structure of the rna genome and definition of virusspecific structural and nonstructural proteins. Jan 20, 20 dengue virus infection has become a global threat affecting around 100 countries in the world. Health experts have known about dengue fever for more than 200 years. Currently, there is no licensed antiviral agent available against dengue. Dengue is a viral disease spread through mosquito bites.
Dengue is a disease caused by any one of four closely related dengue viruses denv1, denv2, denv3, and denv4. All four denv serotypes are prevalent in the sub tropical regions of. Dengue is a mosquitoborne infection that causes a severe flulike illness dengue fever, and sometimes a potentially lethal complication called dengue haemorrhagic fever. Dengue virus denv infection is the wildest mosquitoborne infection affecting 2. Dengue virus infection in humans is often inapparent 1,6 but can. Dengue, acute, infectious, mosquitoborne fever that is temporarily incapacitating but rarely fatal. Penyebab penyakit demam berdarah ialah virus dengue yang termasuk dalam genus. The mosquito becomes infected when it bites a person who has dengue virus in their blood. Mechanism of dengue virus entry into cells revealed. Dengue fever genetic and rare diseases information center. Dengue fever, an infectious tropical disease caused by a mosquitoborne virus, afflicts millions of people each year, causing fever, headache, muscle and joint pains and a characteristic skin rash.
Dengue fever is an infectious disease carried by mosquitoes and caused by any of four related dengue viruses. This epidemic is not one that faces easy fixes, in fact there is no vaccine for the dengue virus. Dengue fever genetic and rare diseases information. Culicidae disebut blackwhite mosquito, karena tubuhnya ditandai dengan pita atau garisgaris putih. High fever severe nausea mild nosebleeds joint pain. You can be infected by at least two if not all four types at different times during your lifetime, but only once by the same type. The infection is usually mild and passes after about 1 week without causing any lasting problems.
Dengue virus dengue virus is a member of the flaviviridae family, along with yellow fever, west nile, japanese encephalitis and tickborne encephalitis tbe viruses. It is a mosquitoborne, single positivestranded rna virus of the family flaviviridae. Dengue fever df, caused by dengue virus, is an arboviral disease characterized by an initial nonspecific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage dengue hemorrhagic fever, or dhf and shock dengue shock syndrome, or dss. These studies were carried out by light lm, confocal. Dengue fever dengue hemorrhagic fever dhf dengue shock syndrome threats. Mar 16, 2016 wednesday, march 16, 2016 healthday news an experimental vaccine against dengue the mosquitoborne virus behind a very painful illness was found effective in a new study. Dec 27, 2018 dengue is endemic throughout the tropics and subtropics. Dec 01, 2012 dengue fever df, caused by dengue virus, is an arboviral disease characterized by an initial nonspecific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage dengue hemorrhagic fever, or dhf and shock dengue shock syndrome, or dss. Virus pathogen database and analysis resource vipr.
The images also appear when selecting from individual virus names. Dengue is spread by a type of infected mosquito called the aedes aegypti mosquito. Pdf persistency of transovarial dengue virus in aedes aegypti. Dengue is a disease caused by infection with one of the four dengue virus serotypes denv1, 2, 3, and 4. It takes a week or more for the dengue virus to replicate in the mosquito. The global distribution and burden of dengue nature. The table includes total number of cases reported in the united states, by region and by states, in accordance with the current method of. Four distinct serotypes of the dengue virus dengue 1, dengue 2, dengue 3, and dengue 4 exist, with numerous virus strains found worldwide. Reservoir hosts for the virus are monkeys and above all, humans. Dengue virus is a small virus that carries a single strand of rna as its genome.
Analysis of genotype diversity and evolution of dengue virus. The dengue virus is transmitted to humans through the bites of infected mosquitoes and is most often found in tropical and subtropical regions of the world. The denv2 serotype is divided into six known genotypes such as asian i ai, asian ii aii, american am. Pdf a study was conducted to examine the persistency of transovarial. Most of these images are 1200 x 784 pixels and saved qith quality 12 maximum from photoshop. Penularan transovarial fir pada kedua progeni morfologi nyamuk pale. Epidemiological and molecular features of dengue virus. Transovarial transmission of dengue virus in aedes aegypti mosquitoes is. The mosquito bites during daytime hours, particularly around the hours of dawn and dusk. Csf was examined sparingly due to thrombocytopenia. This disease used to be called breakbone fever because it sometimes causes severe joint and muscle pain that feels like bones are breaking. Barth, 1999 using a member of this genus, dengue virus type 2 den2, dengue2, isolated from human sera and inoculated in the clone c636 mosquito cell line from aedes albopictus. New dengue virus confirmed in india times of india. Dengue virus net is the web resource for anyone interested in dengue.
610 1326 1205 913 1476 340 1255 1123 1517 1589 549 987 170 168 1387 83 347 245 1231 655 107 1368 1208 622 940 896 676 278 1258 724 70 524 514 551 89 116 1214 1051 1039 1353 989 873 376 613 467 1185